Blood Canticle (2003) in a novel by Anne Rice in which she combines the new characters from her novel Blackwood Farm with those from her previous novels in The Vampire Chronicles and The Lives of the Mayfair Witches trilogy.
Centered in New Orleans, Blood Canticle in narrated by Lestat. The protagonist is a young Mayfair witch named Mona. At the beginning of the novel, Mona is wasting away, victim to a mysterious disease brought on by the birth of her daughter, a so-called Walking Baby. As the novel plays out, Mona and her guardian, Rowan Mayfair, the current designee of the Mayfair legacy, reveal more and more about the powerful genetic plague that has haunted the Mayfairs for generations : the Taltos.
In what she believes to be her dying hour, Mona - highly romantic in nature - buys quantities of rose and takes them to the house of her lover, Tarquin "Quinn" Blackwood, who is a vampire and a dear companion to Lestat. She lays the roses on his bed, intending for Lestat to make her a vampire. He does this largely to satisfy Quinn, who could never again hear the thoughts of Mona if he were to do it himself.
When trying to prevent Mona's family from discovering her transformation, Lestat unwillingly falls in love with Rowan Mayfair. Secretly, she pines for him as well.
Lestat's blood is powerful; Mona learns this quickly and discovers that she can easily dispatch inferior vampires with the powerful gifts that Lestat's potent blood has bestowed upon her. Now her renewed vigor and her anger about her situation with Rowan and their shared secret of the Taltos causes her to lash out verbally at Rowan and Rowan's husband, Michael Curry. As she struggles with herself, Lestat and Quinn, she learns her place in her new world.
As she learns, Lestat pledges to find her Taltos child it if still lives. For this, Lestat enlists the help of Maharet. In a very short time, Maharet provides critical information for their search.
The story comes to a dramatic conclusion as Mona, journeying with Quinn and Lestat comes to the remote island where the Taltos live. But instead of finding a secluded paradise, the three vampires learn about years of intrigue and civil war among this isolated race of beings. In the end, the remaining Taltos join the Mayfair clan at the medical center in New Orleans, where they can be safe, learn, and be together as a family.
Rowan Mayfair seeks out Lestat, half in love with him and exhausted by her life, requesting that he gives her the Dark Gift. Lestat declines, pained as he is, because she is a guiding light for the Mayfair family and he cannot take her away from it.